This film includes an image of a 16th-century artist's sketch of depression, as well as physician interviews with many men and women who suffer from depression. Interviews include: an elderly woman who is soft-spoken and agitated, a young woman who tried to commit suicide and is reticent in answering questions, a female schizophrenic who consistently looks down and is unable to say "no," an elderly man who admits that he drinks heavily in response to depression, and a middle-aged business man who feels hopeless. The doctors stress that depression is an illness that can be treated and relieved.

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